TREM2 is a member of the immunoglobulin superfamily. Endogenous ligands of this receptor are unknown but when triggered, it signals through the transmembrane adapter protein …

Jan 23, 2023 · TREM2 antibody sports transferrin receptor binding domain to ease entry into brain. It activated microglia and boosted brain glucose metabolism. The antibody is in a first …

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Aug 31, 2017 · Indeed, Schlepckow found that monocytes expressing H157Y TREM2 phagocytosed a third less Escherichia coli than monocytes expressing the wild-type receptor. …

Mar 13, 2018 · TREM2 knockout microglia also failed to activate and secrete pro-inflammatory cytokines in response to Aβ. To see if this held true in vivo, the authors injected Aβ into the …

May 10, 2019 · Two groups claim to have found antibodies that activate TREM2. An antibody against CD33 has entered trials. The epigenetic regulator apabetalone dampens …

The agonists worked with the known TREM2 AD risk variants and in conjunction with endogenous TREM2 ligands. For example, one agonist upped the maximal response to sulfatide, a …

TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis. JAMA Neurol. 2014 Apr;71 (4):449-53. PubMed. Chen X, Chen Y, Wei Q, Guo X, Cao B, Ou R, Zhao B, …

03 Nov 2023 Because certain variants in TREM2 increase a person's risk of developing Alzheimer’s disease, how this microglial receptor influences AD pathology is an area of …

May 21, 2024 · Nonetheless, differences between TREM2-sol and Trem2 knock-out mice ( Trem2-KO) were observed, including prolonged microglial responses to injury, increased …