At its so-called 3' end mRNA is equipped with a polyadenine tail with an average length of 200 nucleotides. But even this shield does not last long -- the average half-life of mRNA is only 7 hours.

At its so-called 3' end, mRNA is equipped with a polyadenine tail with an average length of 200 nucleotides. But even this ...

“These [changes] can define the half-life of the mRNA,” Šiurkus notes. Alternatively, researchers can also modify the chemical structure of the mRNA cap found at the molecule’s 5’ en ...

How does a COVID-19 mRNA vaccine work? COVID vaccines are now available. Some of the COVID-19 vaccines are mRNA vaccines, but what does this mean? mRNA vaccines are different from traditional ...

Production tips from Crystal Bio, TriLink Biotechnologies, Ginkgo Bioworks, Quantoom Biosciences, and Parexel.

However, the speed of vaccine production is limited because the mRNA used in it is partly chemically synthesized and partly synthesized using enzymes, a relatively slow process. A team of ...

difficile or C. diff. In animal models, this first mRNA-LNP C. difficile vaccine was found to protect against C. difficile first-time infections and relapsing infections by inducing a robust ...

In 2021, with the COVID-19 pandemic in full swing, BioNTech (NASDAQ:BNTX) and Moderna (NASDAQ:MRNA) were the darlings of the pharma and biotech worlds. The two mRNA therapy developers created ...

Expert Rev Vaccines. 2012;11(1):55-67. A summary of the events taking place after intradermal injection of naked mRNA is given inFigure 1. Although formulation of mRNA vaccines and sophisticated ...