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In humans, the most frequent cause of DCM is a mutation in titin that shortens the protein. DCM affects 1 in 500 people, and often patients must undergo a heart transplant to survive.
The Gautel lab used advanced microscope techniques to watch the molecules link to each other in live cells. "We knew that telethonin acted as a sort of 'cap' or 'bolt' at the end of the titin ...
Titin can stretch to become 1 micron longer—an enormous distance for a single protein—and not only avoid breaking but also continue to pull back with a significant counterforce.
In the field of muscle physiology, scientists study muscle movement at the molecular level—chiefly, proteins such as myosin, actin and titin—to understand how muscles contract.
Proteins – the building blocks of life – consist of a long chain of molecules called amino acids folded into a 3D shape. An atomic force microscope (AFM) can be used to study this folding by attaching ...
An interferometer-based atomic force microscope has revealed the viscosity and elasticity of a single molecule of a folded giant muscle protein called titin 1. The study could help understand and ...
The Titin protein itself has some remarkable properties, but its sheer size makes it almost impossible to work with. In a world where proteins that are 300 amino acids long are common, Titin ...
Titin, named after the titans of Greek mythology, is the largest protein in animals and plays a critical role as the structural linchpin of sarcomeres, the contractile units of muscle cells.
Titin, named after the titans of Greek mythology, is the largest protein in animals and plays a critical role as the structural linchpin of sarcomeres, the contractile units of muscle cells.
Now, in a study in zebrafish and human heart muscle cells, researchers show that a tiny deletion in the A-band of titin—the loss of just nine amino acids out of more than 27,000 to 35,000 amino ...
European Molecular Biology Laboratory. (2006, January 16). Giant Protein Titin Helps Build Muscles. ScienceDaily. Retrieved June 3, 2025 from www.sciencedaily.com / releases / 2006 / 01 ...