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New study highlights senescent cell removal mechanisms of canagliflozin, a sodium glucose co-transporter 2 inhibitor
Sure enough, SGLT2 inhibition with canagliflozin significantly reduced the previously elevated number of PD-L1-positive senescent cells in HFD-fed mice. Conversely, suppression of immune cells ...
Science Daily3d
Researchers make glioblastoma cells visible to attacking immune cells
Researchers have identified a possible way to make glioblastoma cells vulnerable to different types of immunotherapy. The strategy, which they demonstrated in cells in the lab, forces brain cancer ...
Medscape6d
The Role of Kidney in Glucose Homeostasis — SGLT2 Inhibitors, a New Approach in Diabetes Treatment
Renal glucose reabsorption involves two transporter families: the SGLTs secondary active Na + /D-glucose co-transporters located at the brush border of tubular cells (SGLT2 and SGLT1) and the ...
News Medical5h
GLP-1 and SGLT2 inhibitors show promise in preventing recurrent stroke and heart attack
GLP-1 receptor agonists and SGLT2 inhibitors, two classes of medications most commonly prescribed to treat Type 2 diabetes or weight loss, may reduce the risk of heart attack, second strokes and death ...
Medical Xpress17d
Analyzing heart and kidney outcomes after canagliflozin treatment in older adults
A recent analysis of clinical trial data reveals that the SGLT2 inhibitor canagliflozin benefited patients across all age categories. The findings were presented at ASN Kidney Week 2024 October 23 ...
Medscape5d
Intranasal Insulin Drug Combo Promising for Alzheimer’s
The combination of intranasal insulin (INI) and the sodium-glucose cotransporter 2 inhibitor (SGLT2i) empagliflozin had ...