1 This means miRNA guides can target any mRNA with homology to its seed region ... In contrast, when RNAi is guided by siRNA, the entire sequence pairs with the target strand with high complementarity ...

This important manuscript provides insights into the competition between Splicing Factor 1 (SF1) and Quaking (QKI) for binding at the ACUAA branch point sequence in a model intron, regulating exon ...

StitchR, a new gene therapy technique, delivers large genes in two parts to treat muscular dystrophies by restoring critical proteins in animal models.

The article by Sarfaraz K. Niazi, PhD, argues that the FDA’s classification of future copies of messenger RNA (mRNA) products ...

Gene therapy can effectively treat various diseases, but for some debilitating conditions like muscular dystrophies there is a big problem: size.

Production tips from Crystal Bio, TriLink Biotechnologies, Ginkgo Bioworks, Quantoom Biosciences, and Parexel.

Singapore has launched Asia's first automated mRNA manufacturing facility, which will speed up vaccine production in the country. The BioFoundry can be ramped up during a health crisis ...

This valuable study reveals extensive binding of eukaryotic translation initiation factor 3 (eIF3) to the 3' untranslated regions (UTRs) of efficiently translated mRNAs in human pluripotent stem ...

difficile or C. diff. In animal models, this first mRNA-LNP C. difficile vaccine was found to protect against C. difficile first-time infections and relapsing infections by inducing a robust ...

difficile or C. diff. In animal models, this first mRNA-LNP C. difficile vaccine was found to protect against C. difficile first-time infections and relapsing infections by inducing a robust ...

The idea that speckles might be storage sites for spliceosomes triggered Guttman to look deeper into how nuclear organization ...

Large vaccine companies are reluctant to invest too heavily in the emerging technology due to a gap in knowledge, especially compared to mRNA therapeutics. Despite this, those familiar with ...