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Interestingly, these effects occurred without compromising sarcomeric integrity. The study further identified increased binding of the titin-binding protein Four-and-a-Half Lim domains 2 (FHL2) with ...

Abstract Rare and common genetic variants contribute to the risk of atrial fibrillation (AF). Although ion channels were among the first AF candidate genes identified, rare loss-of-function variants ...

Pilot projects are research projects carried out by doctoral researchers and postdocs from working groups in the Cells in Motion Interfaculty Centre. In interdisciplinary teams, they can plan and ...

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titin (Figure 2B). Lastly, a gene ontology enrichment analysis was performed to identify overlapping differentially expressed pathways. The top upregulated pathways for ESC-derived myogenic ...

Figure 1. Top, Schematic diagram of mitral inflow and mitral medial annulus velocities from normal to progressive stages of diastolic dysfunction. Mitral inflow E is sensitive to preload, becoming ...