Despite the diverse nature of obesity, there is compelling genetic, clinical, and experimental evidence that endorses the ...

The nucleus is the double membrane limited structure within an eukaryotic cell that contains the chromosomes, and where the DNA is replicated or transcribed into RNA. The membrane is perforated by ...

In mammals, circadian rhythms are controlled by the suprachiasmatic nucleus (SCN) – a small part of the ... including a higher risk of cardiometabolic disease and type 2 diabetes. Although these ...

This study provides convincing evidence for functional subpopulations of β-cells responsible for Ca2+ signal initiation and maintenance using novel three-dimensional light sheet microscopy imaging and ...

Hypoglycemia is an extremely common side effect of insulin therapy experienced mainly by patients with type 1 diabetes ...

It is one of the most important regulators of food intake and energy homeostasis. It comprises several distinct nuclei, among which the ventromedial hypothalamic nucleus (VMH) was the first to be ...

Nucleus RadioPharma, co-founded by Mayo Clinic, plans to build facilities in Mesa, Arizona and Springhouse, Pennsylvania. The start-up is also creating a manufacturing center in downtown Rochester ...

Single nucleus RNA sequencing (snRNA-seq), an alternative to single cell RNA sequencing (scRNA-seq), encounters technical challenges in obtaining high-quality nuclei and RNA, persistently hindering ...

Understanding the mechanics behind transcription-dependent motions of single genes in the nucleus might be critical for understanding the human genome in health and disease." The human genome ...

Two years after emerging with its initial funding round, CDMO Nucleus RadioPharma is going bicoastal, revealing expansions at two sites that the company believes will "significantly improve ...

This is why people have always thought that every ribosome is the same, and that they just passively churn out protein as dictated by the cell's nucleus. We've now shown that this is not ...

The researchers analyzed brain volume in key subcortical structures, including the brainstem, hippocampus, amygdala, thalamus, nucleus accumbens, putamen, caudate nucleus, globus pallidus and ...