At its so-called 3' end mRNA is equipped with a polyadenine tail with an average length of 200 nucleotides. But even this shield does not last long -- the average half-life of mRNA is only 7 hours.

At its so-called 3' end, mRNA is equipped with a polyadenine tail with an average length of 200 nucleotides. But even this ...

Production tips from Crystal Bio, TriLink Biotechnologies, Ginkgo Bioworks, Quantoom Biosciences, and Parexel.

However, the speed of vaccine production is limited because the mRNA used in it is partly chemically synthesized and partly synthesized using enzymes, a relatively slow process. A team of ...

difficile or C. diff. In animal models, this first mRNA-LNP C. difficile vaccine was found to protect against C. difficile first-time infections and relapsing infections by inducing a robust ...

In 2021, with the COVID-19 pandemic in full swing, BioNTech (NASDAQ:BNTX) and Moderna (NASDAQ:MRNA) were the darlings of the pharma and biotech worlds. The two mRNA therapy developers created ...

The mRNAs are formulated in novel patented lipid nanoparticles, which prolong the half-life of the mRNA and deliver it to immunoactive antigen-presenting cells, which enhances T-cell responses.

Expert Rev Vaccines. 2012;11(1):55-67. A summary of the events taking place after intradermal injection of naked mRNA is given inFigure 1. Although formulation of mRNA vaccines and sophisticated ...

Seven years after being announced, Project Borealis - a fan-developed game based on an unused story treatment for Half-Life 2: Episode 3 - has a playable ten-minute Prologue on Steam. Project ...

I shouldn’t say this out loud because it feels like I’m jinxing things, but I think Half-Life 3 might actually be getting closer. Combined with some of the hints, leaks, and rumors from the ...

The phosphorylation reagent with a nitrobenzyl hydrophobic tag allows production of high purity fully chemically synthesized mRNA and transcriptionally synthesized cyclic mRNA. In an era where ...