The second "toxic" phase begins one or two days later, as the virus attacks the internal organs such as the kidneys and liver. Victims become jaundiced and yellowed, hence the name yellow fever.

The virus particle comes apart, releasing the viral genome. The viral RNA (vRNA) is translated into a single polypeptide that is cut into ten proteins, and the viral genome is replicated.

Dengue Virus Genome and Structure The dengue virus genome ... Chakraborty, T. Dengue Fever and Other Hemorrhagic Viruses. New York: Chelsea House, 2008. Halstead, S. B. Dengue hemorrhagic fever ...