After Demi Moore lost the best actress Oscar to a younger star, Mikey Madison, fans of "The Substance" couldn't help but point out the irony.

Mikey Madison, at 25, is the ninth-youngest best actress winner. Sean Baker is the first person to win four Oscars for the same movie: He produced, directed, wrote and edited it, winning statues for every hat he wore.

Demi Moore, whose movie credits date back to the start of the 1980s, has won virtually nothing of note in all those years. Her nomination for The Substance, a satiric body-horror movie in which she plays an aging star undone by what’s supposed to be a revitalizing serum,