From 1975-2020, the Creighton Bluejays didn’t have a single March Madness Sweet 16 showing, but they’ve done it in three of the past four seasons. They are facing an uphill battle to extend that streak (a 7-5 start to the season hurt their resume significantly,

Madness picks, predictions, odds for Creighton vs Louisville first-round South Region game on Thursday, March 20, 2025.

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