San Francisco 49ers running back Christian McCaffrey was activated off injured reserve on Saturday and is set to make his NFL season debut on Sunday when the Niners play in Tampa Bay against the Buccaneers.

We have four teams on bye and a Sunday morning Germany game this week, lightening the main slate injury report to a certain degree. However, there are some very big names both coming and going, including one of the league's top quarterbacks likely heading for season-ending surgery and a top-flight running back expected to make his long-awaited season debut.

To help you set your fantasy football lineups and avoid starting a player on offense who won't be in the lineup, we'll post fantasy-relevant updates and analysis here as NFL teams release their official inactives lists.

Projecting fantasy points for Christian McCaffrey this week against the Buccaneers, plus stats, insights and more.

Week 10 started with a bang, as Ja’Marr Chase went bananas for 55.4 fantasy points. And as we headed into Sunday night, no wideout was within 29 points of him (

Fantasy football just hasn’t quite been the same this year without star running back Christian McCaffrey in lineups across the nation. He's almost back.

Here we are at Election Day, and our long national nightmare is about to end. That’s right, Christian McCaffrey is on the cusp of making his season debut.

PM ET, WR Nico Collins and the Houston Texans match up with the Detroit Lions, who have the 29th-ranked pass defense in the NFL (250.8 receiving yards allowed per game). Is Collins' game against the Lions this week a good time to start him in fantasy?