Little Britain is an unincorporated community and census-designated place in Little Britain Township, Lancaster County, Pennsylvania, United States. At the 2010 census, the population was 372. Little Britain is in far southern Lancaster County, in the center of Little Britain Township. Pennsylvania Route 272 passes through the center of the community, leading north…Little Britain is an unincorporated community and census-designated place in Little Britain Township, Lancaster County, Pennsylvania, United States. At the 2010 census, the population was 372. Little Britain is in far southern Lancaster County, in the center of Little Britain Township. Pennsylvania Route 272 passes through the center of the community, leading northwest 23 miles to Lancaster, the county seat, and southeast 6 miles to Nottingham in Chester County.