SGLT2 inhibition eliminates senescent cells and alleviates ... - Nature
WEBMay 30, 2024 · SGLT2 inhibition affects programmed cell death-ligand 1 expression by senescent cells. Senescent cells that accumulate in tissues activate the immune system by secreting SASP factors. The ...
SGLT2 regulates immune-mediated senolysis | Nature Aging
WEBJun 10, 2024 · Katsuumi and colleagues now show that, in addition to their glycemic effects, SGLT2 inhibitors modulate senescence immune surveillance by downregulating PD-L1 expression on senescent cells.
Immunomodulatory Effects of SGLT2 Inhibitors—Targeting …
WEBAug 29, 2023 · There is a growing body of evidence supporting the beneficial effects of SGLT2 inhibitors on the mTOR, AMPK, and SIRT1 pathways in various tissues and cells, including kidney, pancreas, hepatocytes, cardiac microvascular endothelial cells, cardiomyocytes, and adipocytes [24,25,26,27,28,29,30].
WEBto their glycemic e˜ects, SGLT2 inhibitors modulate senescence immune surveillance by downregulating PD-L1 expression on senescent cells.
Unveiling the anticancer effects of SGLT-2i: mechanisms and …
WEBMar 26, 2024 · SGLT2 inhibitor activates the STING/IRF3/IFN-β pathway and induces immune infiltration in osteosarcoma. Cell Death Dis. 13 (6), 523. 10.1038/s41419-022-04980-w [PMC free article] [Google Scholar] Xia H., Chen J., Gao H., Kong S. N., Deivasigamani A., Shi M., et al. (2020).
SGLT2 inhibition eliminates senescent cells and alleviates
WEBThese findings suggest that inhibition of SGLT2 has an indirect senolytic effect by enhancing endogenous immunosurveillance of senescent cells.
Repurposing SGLT2 inhibitors for autoimmune diseases? YES ... - Cell …
WEBSep 21, 2023 · In the July 11 issue of Cell Metabolism, Jenkins et al. describe how a type 2 diabetes drug, canagliflozin, can be repurposed for the treatment of autoimmune disorders through metabolic reprogramming of the T cell response.
Unlocking the Full Potential of SGLT2 Inhibitors: Expanding ...
WEBMar 23, 2023 · SGLT2 inhibitor has been shown to inhibit glucose uptake by SGLT2-expressing human liver cancer cells (Huh7 and HepG2) at clinically comparable doses and in a dose-dependent manner, reduce intracellular adenosine triphosphate (ATP) levels, induce cell apoptosis, and indirectly suppress tumor angiogenesis . Additionally, some research has shown ...
WEBImmune cells, such as T cells, play a central role in developing this pro-in-flammatory autoimmune environment by recognizing and responding to the self-antigens presented by antigen-presenting cells.
Targeting inflammatory signaling pathways with SGLT2 inhibitors ...
WEBMay 1, 2024 · SGLT2 inhibitors on immune cells modulation Macrophages. SGLT2 inhibitors, have recently drawn attention for their role in immune regulation, specifically in modulating macrophage polarization. This function is crucial in immune responses, with SGLT2 inhibitors facilitating a transition from the pro-inflammatory M1 (macrophage 1) phenotype to ...
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